PNAS paper on Systemic Genomic Instability by Dr. Nishant K.T’s group along with collaborators

Dr. Nishant K.T’s group (School of Biology) along with collaborators from Colorado State University and the University of North Carolina, published a paper in PNAS USA characterizing systemic genomic instability using yeast as a model.

Mutations are conventionally thought to accumulate independently and gradually over many generations. In this publication, the authors used budding yeast to track the appearance of chromosomal changes resulting in loss-of-heterozygosity. In contrast to the prevailing model, their results provide evidence for the existence of a path for nonindependent accumulation of multiple chromosomal alteration events over a few generations.

This result suggests systemic genomic instability that is also observed in cancer cells and provides a tractable system to study such punctuated bursts of mutation accumulation.

The research is published in the latest issue of PNAS USA (