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Indian Institute of Science Education and Research
Thiruvananthapuram

Dr Sreejith Jayasree Varma
Assistant Professor Grade I (Chemistry)
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  1. Aulakh, S. K.; Vidal, L. S.; South, E. J.; Peng, H.; Varma, S. J.; Herrera-Dominguez, L.; Ralser, M.; Ledesma-Amaro, R.: Spontaneously established syntrophic yeast communities improve bioproduction. Nat. Chem. Biol., 2023, 951. 
  2. Correia-Melo, C.; Kamrad, S.; Tengölics, R.; Messner, C. B.; Trebulle, P.; Townsend, SJ.; Varma, S. J.; Freiwald, A.; Heineike, B. M.; Campbell, K.; Herrera-Dominguez, L.; Aulakh, S.K.; Szyrwiel, L.; Jason, S. L.; Zelezniak, A.; Demichev, V.; Mülleder, M.; Papp, B.; Alam, M. T.; Ralser, M.: Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan. Cell, 2023, 186, 63. 
  3. Aulakh, S. K.; Varma, S. J.; Ralser, M.: Metal ion availability and homeostasis as drivers of metabolic evolution and enzyme function. Curr. Opin. Genet. Dev., 2022, 77, 101987. 
  4. Varma, S. J.; Calvani, E.; Grüning, N. M.; Messner, C. B.; Grayson, N.; Capuano, F.; Mülleder, M.; Ralser, M.: Global analysis of cytosine and adenine DNA modifications across the tree of life. Elife, 2022, 11, e81002.
  5. Piedrafita, G.; Varma, S. J.; Castro, C.; Messner, C. B.; Szyrwiel, L.; Griffin, J. L.; Ralser, M.: Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure. PLoS Biol., 2021, 19, e3001468.
  6. Ralser, M.; Varma, S. J.; Notebaart, R. A.: The evolution of the metabolic network over long timelines. Curr. Opin. Syst. Biol., 2021, 58, 100402. 
  7. Muchowska, K. B.; Varma, S. J.; Moran, J.: Nonenzymatic metabolic reactions and life’s origins. Chem. Rev., 2020, 120, 7708.
  8. Preiner, M.; Igarashi, K.; Muchowska, K. B.; Yu, M.; Varma, S. J.;Kleinermanns, K.; Nobu, M. K.; Kamagata, Y.; Tüysüz, H.; Moran, J.; Martin, W. F.: A hydrogen-dependent geochemical analogue of primordial carbon and energy metabolism. Nature Eco. Evo., 2020, 4, 534. 
  9. Muchowska, K. B.; Varma, S. J.; Moran, J.: Synthesis and breakdown of universal metabolic precursors promoted by iron. Nature, 2019, 569, 104. 
  10. Varma, S. J.; Muchowska, K. B.; Chatelain, P.; Moran, J.: Native iron reduces CO2 to intermediates and end-products of the acetyl CoA pathway. Nature Eco. Evo., 2018, 2, 1019.
  11. Muchowska, K. B.; Varma, S. J.; Chevallot-Beroux, E.; Lethuillier-Karl, L.; Li, G.; Moran, J: Metals promote sequences of the reverse Krebs cycle. Nature Eco. Evo., 2017, 1, 1716. 
  12. Chauhan, D. P; Varma, S. J.; Gudem, M.; Panigrahi, N.; Singh, K.; Hazra, A.; Talukdar, P.: Intramolecular cascade rearrangements of enynamine derived ketenimines: Access to acyclic and cyclic amidines. Org. Biomol. Chem., 2017, 15, 4822. 
  13. Thomas, A.; George, J.; Shalabney, A.; Dryzhakov, M.; Varma, S. J.; Moran, J.; Chervy, T.; Zhong, X.; Devaux, E.; Genet, C.; Hutchison, J. A.;Ebbesen, T. W.: Ground-state chemical reactivity under vibrational coupling to the vacuum electromagnetic field. Angew. Chem. Int. Ed., 2016, 55, 11462. 
  14. Chauhan, D. P.; Varma, S. J.; Vijeta, A.; Banerjee, P.; Talukdar, P.: 1,3-Amino group migration route to form acrylamidines. Chem. Commun., 2014, 50, 323. 
  15. Kand, D.; Varma, S. J.; Kalle, A. M; Talukdar, P.: A chromenoquinoline-based fluorescent off–on thiol probe for bioimaging. Chem. Commun., 2012, 48, 2722.