Lysosomes play a crucial role in the degradation and recycling of macromolecules received from endocytic and autophagic pathways. Defects due to gene mutations cause lysosomal degradation defects, resulting in the accumulation of undigested material leading to lysosomal storage disorders. Lysosomal storage disorders are debilitating diseases characterized mainly by developmental delay, neurodegeneration, dementia, and epileptic seizures.

The focus of the lab is to find the cell biological basis of lysosomal storage disorders that lead to therapeutic intervention.