Dr Ayan Mukherjee
Assistant Professor Grade I (Chemistry)
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  1. A. Mukherjee, Vilas D Kadam, Qi Miao, Wanheng Zhang, Kevin R MacKenzie, Zhi Tan, Mingxing Teng, On-demand modular assembly for expedited PROTAC development Expert Opinion on Drug Discovery June (2024) 1-4.
  2. Ramirez, S. Dhiman, A. Mukherjee, R. Wimalasekara, F. Schweizer, Application of tobramycin benzyl ether as an antibiotic adjuvant capable of sensitizing multidrug-resistant Gram-negative bacteria to rifampicin, RSC Medicinal Chemistry 15 (2024) 1055-1065.
  3. A. Mukherjee, D. Ramirez, R. Arora, G. Arthur, F. Schweizer, Amphiphilic tribasic galactosamines potentiate rifampicin in Gram-negative bacteria at low Mg++/Ca++concentrations, Bioorg Med Chem Lett. (2023) 129371.
  4. Miao, V.D. Kadam, A. Mukherjee, Z. Tan, M. Teng, Unlocking DCAFs To Catalyze Degrader Development: An Arena for Innovative Approaches, J Med Chem. (2023). 13369-13383
  5. Talukdar*, A. Mukherjee*, D. Bhattacharya, Fascinating Transformation of SAM-Competitive Protein Methyltransferase Inhibitors from Nucleoside Analogues to Non-Nucleoside Analogues, J. Med. Chem. 65 (2022) 1662–1684.
  6. A. Bezerra, A. Holenstein, W.R. Foster, B. Xie, K.G. Hicks, C. Bürer, S. Lutz, A. Mukherjee, D. Sarkar, D. Bhattacharya, J. Rutter, A. Talukdar, P.J. Brown, M. Luo, L. Shi, D.S. Froese, W.W. Yue, Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain, Biochimie. 183 (2021) 100–107.
  7. Kundu, D. Raychaudhuri, A. Mukherjee, B.P. Sinha, D. Sarkar, P. Bandopadhyay, S. Pal, N. Das, D. Dey, K. Ramarao, K. Nagireddy, D. Ganguly, A. Talukdar, Systematic Optimization of Potent and Orally Bioavailable Purine Scaffold as a Dual Inhibitor of Toll-Like Receptors 7 and 9, J. Med. Chem. 64 (2021) 9279–9301. 1= Contribute Equally
  8. A. Mukherjee, D. Raychaudhuri, B. P. Sinha, B. Kundu, B. Paul, D. Ganguly, A. Talukdar, Chemical switch for transforming a purine agonist for toll-like receptor 7 to a clinically relevant antagonist. J. Med. Chem. 63 (2020) 4776–4789.
  9. A. Mukherjee, S. Mishra, N. K. Kumar, K. Manna, S. Roy, B. Kundu, D. Bhattacharya, K. D. Saha and A. Talukdar, Semisynthetic Quercetin Derivatives with Potent in Vitro and in Vivo Antitumor Activity in Colon Carcinoma, ACS Omega 4 (2019) 7285-7298.
  10. Kundu, S.K. Das, S. Paul Chowdhuri, S. Pal, D. Sarkar, A. Ghosh, A. Mukherjee, D. Bhattacharya, B.B. Das, A. Talukdar, Discovery and Mechanistic Study of Tailor-Made Quinoline Derivatives as Topoisomerase 1 Poison with Potent Anticancer Activity, J. Med. Chem. 62 (2019) 3428–3446.
  11. Paul, O. Rahaman, S. Roy, S. Pal, S. Satish, A. Mukherjee, A.R. Ghosh, D. Raychaudhuri, R. Bhattacharya, S. Goon, D. Ganguly, A. Talukdar, Activity-guided development of potent and selective toll-like receptor 9 antagonists, Eur. J. Med. Chem. 159 (2018) 187–205.
  12. Roy, A. Mukherjee, B. Paul, O. Rahaman, S. Roy, G. Maithri, B. Ramya, S. Pal, D. Ganguly, A. Talukdar, Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism, Eur. J. Med. Chem. 134 (2017) 334–347.
  13. Roy, B. Paul, A. Mukherjee, B. Kundu, A. Talukdar, Copper-catalyzed selective C–N bond formation with 2-amino, 2-hydroxy and 2-bromo-5-halopyridine, RSC Adv. 7 (2017) 44366–44370.

Patents

  1. A. Mukherjee, D. Raychaudhuri, B. Kundu, B. Paul, S. Roy, O. R. Rahaman, D. Ganguly, A. Talukdar, Purine based compounds as toll-like receptor 9 antagonist (2019) WO 2019/092739 A1
  2. B. Paul, A. Mukherjee, S. Roy, A. Ghosh, R. Bhattacharya, O. R. Rahaman, B. Kundu, D. Ganguly, A. Talukdar, Blocking toll-like receptor 9 signalling with small molecule antagonist. (2017), WO 2017163264 A1.
  3. B. Kundu, A. Mukherjee, S. K. Das, S. P. Chowdhuri, D. Sarkar, S. pal, D. Bhattacharya, S. Roy, A. Talukdar, B. B. Das, Bicycle topoisomerase I inhibiting compounds, process for preparation and use thereof, (2019) WO/2019/229765

Book Chapter

  1. Talukdar, A. Mukherjee, D. Ganguly, chapter 13 Small Molecule Modulators of Endo-lysosomal Toll-like Receptors, in: Protein–Protein Interaction Regulators, The Royal Society of Chemistry, 2021: pp. 339–372.