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Faculties

Dr Nishant KT

Associate Professor

Email : bmlzaGFudGt0QGlpc2VydHZtLmFjLmlu , Phone :  +91 (0)471 2593190

Web Link  : http://faculty.iisertvm.ac.in/nishantkt/

Publications

1.  Rodrigues-Prause, A., Sampaio, N.M.V., Gurol, T.M., Aguirre, G.M., Sedam, H.N.C., Chapman, M.J., Malc, E.P., Ajith, V.P., Chakraborty, P., Tizei, P.A., Pereira, G.A.G., Mieczkowski, P.A., Nishant, K.T. and Argueso JL (2018) A case study of genomic instability in an industrial strain of Saccharomyces cerevisiae. G3 (Bethesda), doi: 10.1534/g3.118.200446

2.  Chakraborty, P., Ajith, V.P., Dutta, A. and Nishant, K.T (2018) Genome wide analysis of meiotic recombination in yeast: for a few SNPs more.  IUBMB Life 70: 743-752.

3.  Dutta, A., Lin, G., Pankajam, A.V., Chakraborty, P., Bhat, N., Steinmetz, L.M. and Nishant K.T. (2017) Genome dynamics of hybrid Saccharomyces cerevisiae during vegetative and meiotic divisions.  G3 (Bethesda) 7: 3669-3679.

4. Al-Sweel, N., Raghavan, V., Dutta, A., Ajith, V.P., Di Vietro, L., Khondakar, N., Manhart, C.M., Surtees, J.A., Nishant, K.T. and Alani, E. (2017) Mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide. PLoS Genet. 13: e1006974.

5. Chakraborty, P., Pankajam, A.V.,  Lin, G., Dutta, A., Krishnaprasad, G.N., Tekkedil, M.M., Shinohara, A., Steinmetz, L.M. and Nishant K.T. (2017) Modulating Crossover Frequency and Interference for Obligate Crossovers in Saccharomyces cerevisiae Meiosis. G3 (Bethesda) 7: 1511-1524.

6. Nishant K.T and Sanyal K. (2015) The Good, the bad, and the ugly: How to protect chromosome stability from potential threats. BioEssays 37: 717-720.

7. Krishnaprasad, G.N., Anand, M.T., Lin, G., Tekkedil, M.M., Steinmetz, L.M. and Nishant, K.T. (2015) Variation in crossover frequencies perturb crossover assurance without affecting meiotic chromosome segregation in Saccharomyces cerevisiae. Genetics 199: 399-412.

8. Rakshambikai, R., Srinivasan, N. and Nishant, K.T. (2013) Structural insights into Saccharomyces cerevisiae Msh4-Msh5 complex function using homology modeling. PLoS One 8: e78753.

9. Brown, M.S., Lim, E., Chen, C., Nishant, K.T. and Alani, E. (2013) Genetic Analysis of mlh3 Mutations Reveals Interactions Between Crossover Promoting Factors During Meiosis in Baker's Yeast. G3 (Bethesda) 3: 9-22.

10. Ma, X*., Rogacheva, M.V*., Nishant, K.T., Zanders, S., Bustamante, C.D., and Alani, E. (2012) Mutation hotspots in yeast caused by long-range clustering of homopolymeric sequences. Cell Reports 1: 36-42.

11. Nishant, K.T*., Wei, W*., Mancera, E*., Argueso, L., Schlattl, A., Delhomme, N., Ma, X., Bustamante, C., Korbel, J., Gu, Z., Steinmetz, M. and Alani, E. (2010) The baker?s yeast diploid genome is remarkably stable in vegetative growth and meiosis. PLoS Genetics 6:e1001109. (Featured in faculty of 1000)

12. Nishant, K.T., Chen, C., Shinohara, M., Shinohara, A. and Alani, E. (2010) Genetic analysis of MSH4-MSH5 shows that baker?s yeast forms excess crossovers that are not required for viability in meiosis. PLoS Genetics 6: e1001083

13. Nishant, K.T., Singh, N. and Alani, E. (2009) Genomic mutation rates: What highthroughput methods can tell us. Bioessays 31: 912-920.

14. Nishant, K.T., Plys, A. and Alani, E. (2008) A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae. Genetics 179: 747-755 (featured in Issue highlights)

15. Nishant, K.T., Kumar, C. and Rao, M.R.S (2006) HumHot: A database of human meiotic recombination hot spots. Nuc.Acids.Res. 34: D25-D28.

16. Nishant, K.T. and Rao, M.R.S. (2006) Molecular features of meiotic recombination hot spots. BioEssays 28: 45-56.

17. Nishant, K.T., Ravishankar, H. and Rao, M.R.S. (2004) Characterization of a mouse recombination hotspot encoding a novel non-protein coding RNA. Mol.Cell.Biol. 24: 5620 ? 5634.

* (Equal contributors)

Book Chapter

Agrawal, S., Nishant, K.T. and Rao, M.R.S (2010) Analysis of Meiotic Recombination Hotspots: A Bioinformatics Approach, In Gabriel Fung?s A Practical Guide to Bioinformatics Analysis (pp. 133-149) Queensland, Australia: iConcept Press.