IISER - TVM

Faculties

Dr Nishant KT

Associate Professor

Email : bmlzaGFudGt0QGlpc2VydHZtLmFjLmlu

Web Link  : http://faculty.iisertvm.ac.in/~nishantkt/

Publications

1.  Dutta, A., Lin, G., Pankajam, A.V., Chakraborty, P., Bhat, N., Steinmetz, L.M. and Nishant K.T. (2017) Genome dynamics of hybrid Saccharomyces cerevisiae during vegetative and meiotic divisions (Manuscript accepted in G3(Bethesda)

2. Al-Sweel, N., Raghavan, V., Dutta, A., Ajith, V.P., Di Vietro, L., Khondakar, N., Manhart, C.M., Surtees, J.A., Nishant, K.T. and Alani, E. (2017) Mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide. PLoS Genet. 13: e1006974.

3. Chakraborty, P., Pankajam, A.V.,  Lin, G., Dutta, A., Krishnaprasad, G.N., Tekkedil, M.M., Shinohara, A., Steinmetz, L.M. and Nishant K.T. (2017) Modulating Crossover Frequency and Interference for Obligate Crossovers in Saccharomyces cerevisiae Meiosis. G3 (Bethesda) 7: 1511-1524.

4. Nishant K.T and Sanyal K. (2015) The Good, the bad, and the ugly: How to protect chromosome stability from potential threats. BioEssays 37: 717-720.

5. Krishnaprasad, G.N., Anand, M.T., Lin, G., Tekkedil, M.M., Steinmetz, L.M. and Nishant, K.T. (2015) Variation in crossover frequencies perturb crossover assurance without affecting meiotic chromosome segregation in Saccharomyces cerevisiae. Genetics 199: 399-412.

6. Rakshambikai, R., Srinivasan, N. and Nishant, K.T. (2013) Structural insights into Saccharomyces cerevisiae Msh4-Msh5 complex function using homology modeling. PLoS One 8: e78753.

7. Brown, M.S., Lim, E., Chen, C., Nishant, K.T. and Alani, E. (2013) Genetic Analysis of mlh3 Mutations Reveals Interactions Between Crossover Promoting Factors During Meiosis in Baker's Yeast. G3 (Bethesda) 3: 9-22.

8. Ma, X*., Rogacheva, M.V*., Nishant, K.T., Zanders, S., Bustamante, C.D., and Alani, E. (2012) Mutation hotspots in yeast caused by long-range clustering of homopolymeric sequences. Cell Reports 1: 36-42.

9. Nishant, K.T*., Wei, W*., Mancera, E*., Argueso, L., Schlattl, A., Delhomme, N., Ma, X., Bustamante, C., Korbel, J., Gu, Z., Steinmetz, M. and Alani, E. (2010) The baker?s yeast diploid genome is remarkably stable in vegetative growth and meiosis. PLoS Genetics 6:e1001109. (Featured in faculty of 1000)

10. Nishant, K.T., Chen, C., Shinohara, M., Shinohara, A. and Alani, E. (2010) Genetic analysis of MSH4-MSH5 shows that baker?s yeast forms excess crossovers that are not required for viability in meiosis. PLoS Genetics 6: e1001083

11. Nishant, K.T., Singh, N. and Alani, E. (2009) Genomic mutation rates: What highthroughput methods can tell us. Bioessays 31: 912-920.

12. Nishant, K.T., Plys, A. and Alani, E. (2008) A mutation in the putative MLH3 endonuclease domain confers a defect in both mismatch repair and meiosis in Saccharomyces cerevisiae. Genetics 179: 747-755 (featured in Issue highlights)

13. Nishant, K.T., Kumar, C. and Rao, M.R.S (2006) HumHot: A database of human meiotic recombination hot spots. Nuc.Acids.Res. 34: D25-D28.

14. Nishant, K.T. and Rao, M.R.S. (2006) Molecular features of meiotic recombination hot spots. BioEssays 28: 45-56.

15. Nishant, K.T., Ravishankar, H. and Rao, M.R.S. (2004) Characterization of a mouse recombination hotspot encoding a novel non-protein coding RNA. Mol.Cell.Biol. 24: 5620 ? 5634.

* (Equal contributors)

Book Chapter

Agrawal, S., Nishant, K.T. and Rao, M.R.S (2010) Analysis of Meiotic Recombination Hotspots: A Bioinformatics Approach, In Gabriel Fung?s A Practical Guide to Bioinformatics Analysis (pp. 133-149) Queensland, Australia: iConcept Press.